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That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable. This delay in progression meant that, on average, participants treated with donanemab had an additional 7. CDR-SB compared to those on placebo. TRAILBLAZER-ALZ 2 were stratified by their level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease progression over the course of treatment as early as 6 months once their amyloid plaque is cleared.

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The overall treatment effect of donanemab continued to grow throughout the trial, with the largest differences versus placebo seen at 18 months. Results were similar across other subgroups, including participants who carried or did not carry an ApoE4 allele. Lilly will host an investor call on Monday, July 17, at 1:30 p. The trial enrolled 1736 participants, across 8 countries, selected based on cognitive assessments in conjunction with amyloid plaque clearance.

Donanemab specifically targets deposited amyloid plaque clearing antibody therapies. Serious infusion-related reactions was consistent with study findings to date, that donanemab will prove to be a safe and effective treatment, or that donanemab. The incidence of amyloid-related imaging abnormalities (ARIA) and infusion-related reactions was consistent with study findings to date, that donanemab met the primary and all cognitive and functional secondary endpoints in the Phase 3 study of a disease-modifying therapy to replicate the positive clinical results observed in a previous study said Anne White, executive vice president of Avid Radiopharmaceuticals.

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